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Complete Guide to Anxiety & Depression Treatment
Evidence-based research compiled into an actionable reference
Why This Exists
Honestly? Curiosity. I wanted to know what actually works for anxiety and depression — not just the standard "exercise and therapy" advice, but the full picture. Effect sizes, mechanisms, what stacks well together.
It's wild that this information isn't easily available in one place. The research exists — thousands of clinical trials, meta-analyses, mechanism studies — but it's scattered across journals, paywalled, and written for academics. Nobody had just... put it all together.
So I did. Used a combination of GPT 5.2x-high and Claude Opus 4.5 with extended thinking to synthesize the research, cross-reference sources, and organize it into something actually useful. The AI did the heavy lifting of reading papers; I curated and structured it.
Not medical advice — I'm not a doctor. But it's a thorough synthesis of what the research actually says.
What's Inside
- 📊Master Ranking — All interventions ranked by clinical effect size (Cohen's d)
- 🌿Supplements — Which ones actually have evidence (and which are noise)
- 🧠Therapy Modalities — CBT, ACT, EMDR, IFS compared head-to-head
- 🏃Lifestyle Interventions — Exercise, sleep, diet, cold exposure
- 🍄Psychedelics Research — Psilocybin, ketamine, MDMA trials
- 🧬Peptides — BPC-157, Semax, Selank research
- 💪Synergistic Stacks — What combines well based on mechanisms
- 💔Shame/Guilt Protocol — Specific approaches for toxic shame
- 📚Sources — 50+ clinical studies and meta-analyses cited
Read the Guide
The full guide is a standalone interactive document with its own navigation and styling.
Open Full Guide ↗Disclaimer: This guide is for educational purposes only. It's a synthesis of published research, not medical advice. Always consult qualified healthcare providers before making treatment decisions.